Sterol carrier protein-x gene and effects of sterol carrier protein-2 inhibitors on lipid uptake in Manduca sexta
نویسندگان
چکیده
منابع مشابه
Sterol carrier protein 2 gene transfer changes lipid metabolism and enterohepatic sterol circulation in mice.
BACKGROUND & AIMS Sterol carrier protein 2 (SCP-2) enhances sterol cycling and facilitates cholesterol translocation between intracellular organelles and plasma membrane in cultured cells, including hepatocytes. We examined the role of SCP-2 in hepatic cholesterol and lipid trafficking through the sinusoidal and canalicular secretory pathways of the liver in vivo. METHODS Recombinant adenovir...
متن کاملIdentification of mosquito sterol carrier protein-2 inhibitors.
A mosquito sterol carrier protein-2, AeSCP-2, has been shown to aid in the uptake of cholesterol in mosquito cells. The discovery of chemical inhibitors of AeSCP-2 is reported here. AeSCP-2 inhibitors (SCPIs) belong to several chemotypes of hydrophobic compounds. Those inhibitors competed with cholesterol for AeSCP-2, binding with relatively high binding affinities. In cultured insect cells, SC...
متن کاملSterol carrier protein-2/sterol carrier protein-x expression differentially alters fatty acid metabolism in L cell fibroblasts.
Sterol carrier protein-2 (SCP-2) and SCP-x are ubiquitous proteins found in all mammalian tissues. Although both proteins interact with fatty acids, their relative contributions to the uptake, oxidation, and esterification of straight-chain (palmitic) and branched-chain (phytanic) fatty acids in living cells has not been resolved. Therefore, the effects of each gene product on fatty acid metabo...
متن کاملParticipation of sterol carrier protein-2 in cholesterol metabolism.
818 Introduction Lipid transport between intracellular organelles is thought to involve carrier proteins. Several different lipid transfer proteins have been isolated which are involved in the transport of phosphatidylcholine, phosphatidylinositol, phosphatidylserine, cholesterol, gangliosides, glycolipids, dolichol and vitamin D3 [ 1-31. In addition to protein mediated transport, other process...
متن کاملInvolvement of sterol carrier protein-2 in dolichol biosynthesis.
The effect of sterol carrier protein-2 (SCP-2) on dolichol biosynthesis by rat liver microsomes was investigated. cis-Prenyltransferase activity was stimulated 7-fold in the presence of 5 micrograms of purified SCP-2/mg of microsomal protein, which was similar to the increase obtained by adding detergent. The polyisoprenoid pattern obtained in the presence of SCP-2 was the same as that present ...
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ژورنال
عنوان ژورنال: BMC Physiology
سال: 2010
ISSN: 1472-6793
DOI: 10.1186/1472-6793-10-9